Description

Iodotrimethylsilane is a highly reactive organosilicon reagent primarily used as a powerful silylating and desilylating agent. Its core value lies in its ability to efficiently cleave ethers and esters, making it indispensable for protecting group manipulation and functional group interconversion in complex syntheses. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the selective deprotection of silyl ethers and the synthesis of complex drug molecules.
• Agrochemical Production: Used in the manufacture of advanced pesticides and herbicides requiring precise silicon-containing intermediates.
• Polymer & Material Science: Acts as a modifier and cross-linking agent in the production of silicone-based polymers and specialty materials.
• Organic Synthesis: Employed for the conversion of alcohols to alkyl iodides and for the cleavage of methyl ethers to their corresponding alcohols.
• Peptide Chemistry: Useful in the deprotection of silyl-protected amino acids during solid-phase peptide synthesis.
• Analytical Derivatization: Serves as a derivatization agent in gas chromatography for analyzing compounds with active hydrogens.

Basic Information

Product Name	Iodotrimethylsilane
CAS No.	16029-98-4
Molecular Formula	C3H9ISi
Molecular Weight	200.09 g/mol
Synonyms	Trimethylsilyl iodide; TMSI; Iodotrimethylsilicon; Trimethyliodosilane; (Iodomethyl)dimethylsilane; Iodotrimethylsilane, 97%; Trimethylsilyl iodide solution; Trimethyl(iodo)silane
EINECS	240-161-3

Quality Control

Our Iodotrimethylsilane is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and industrial applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including custom purity grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C) under an inert atmosphere such as nitrogen or argon due to its sensitivity to moisture and air. Keep away from heat, sparks, and open flame. Isolate from incompatible materials such as strong bases, oxidizing agents, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 97.0%
Density (at 20°C)	1.40 - 1.45 g/mL
Refractive Index (n20D)	1.480 - 1.490
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.