Description

2-(2-Methoxyethoxy)Acetyl Chloride is a versatile and highly reactive acid chloride derivative, primarily used as a key building block in advanced organic synthesis. Its unique structure, featuring an ethylene glycol methyl ether side chain, makes it particularly valuable for introducing polar, hydrophilic moieties into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries who require precise functionalization and reliable scale-up for their synthetic processes.

Application

• Pharmaceutical Intermediates: A critical reagent for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring PEG-like side chains for improved solubility and pharmacokinetics.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators where its polar group can enhance systemic activity and bioavailability.
• Polymer Modification: Serves as a functional monomer or cross-linking agent for creating specialty polymers with tailored properties like hydrophilicity, adhesion, or biocompatibility.
• Surface-Active Agent Precursor: Employed in the manufacture of non-ionic surfactants and emulsifiers for industrial and cosmetic formulations.
• Ligand and Chelator Synthesis: Useful in the preparation of complexing agents and ligands for catalysis or metal ion sequestration.
• Bioconjugation Chemistry: Acts as a linker molecule for attaching polyethylene glycol (PEG) chains or other functional groups to proteins, peptides, or other biomolecules.
• Material Science Research: A valuable tool for academic and industrial R&D in developing new functional materials, coatings, and dendrimers.
• Fine Chemical Production: Integral to multi-step synthetic routes for producing complex organic molecules in research and pilot-scale manufacturing.

Basic Information

Product Name	2-(2-Methoxyethoxy)Acetyl Chloride
CAS No.	16024-55-8
Molecular Formula	C5H9ClO3
Molecular Weight	152.57 g/mol
Synonyms	2-(2-Methoxyethoxy)acetyl chloride; Acetyl chloride, 2-(2-methoxyethoxy)-; 2-(2-Methoxyethoxy)ethanoyl chloride; 2-Methoxyethoxyacetyl chloride; Diethylene glycol methyl ether acyl chloride; Glyme-2 acyl chloride; (2-Methoxyethoxy)acetic acid chloride; 16024-55-8
EINECS	240-163-6

Quality Control

Our 2-(2-Methoxyethoxy)Acetyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including assay by titration and impurity profiling by gas chromatography (GC), to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications, ensuring reliable supply chain integrity and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to minimize decomposition and maintain stability. Due to its highly volatile and hygroscopic nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and hydrolysis. Keep away from heat, sparks, open flames, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (Karl Fischer)	≤ 0.5%
Density (at 20°C)	1.15 - 1.20 g/mL
Refractive Index (n20D)	1.435 - 1.445

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.