Description

2',3'-o-(Isopropylidene)Uridine 5'-Acetate is a key protected nucleoside derivative, serving as a crucial synthetic intermediate in organic and medicinal chemistry. Its primary value lies in providing a reactive handle at the 5'-position while protecting the 2',3'-diol, enabling precise and efficient oligonucleotide synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who are developing novel nucleoside analogs, antiviral agents, and oligonucleotide-based therapeutics. Its consistent high purity is critical for ensuring the success and reproducibility of downstream synthetic processes.

Application

• Pharmaceutical Intermediate: A vital building block for the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Oligonucleotide Synthesis: Used in the preparation of modified RNA and DNA strands for research, diagnostics, and therapeutic applications (e.g., antisense oligonucleotides, siRNA).
• Prodrug Development: Serves as a precursor in creating prodrug forms of bioactive nucleosides to enhance bioavailability and targeting.
• Bioconjugation: The acetate group provides a site for further chemical modification and conjugation with other molecules, such as fluorophores or targeting ligands.
• Chemical Biology Research: Employed in studying nucleic acid structure, function, and metabolism.
• Process Chemistry: Used in scale-up manufacturing of active pharmaceutical ingredients (APIs) requiring protected nucleoside intermediates.

Basic Information

Product Name	2',3'-o-(Isopropylidene)Uridine 5'-Acetate
CAS No.	15922-23-3
Molecular Formula	C14H18N2O7
Molecular Weight	326.30 g/mol
Synonyms	5'-O-Acetyl-2',3'-O-isopropylideneuridine; 2',3'-O-Isopropylideneuridine 5'-acetate; 1-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; Uridine, 2',3'-O-(1-methylethylidene)-, 5'-acetate; 2',3'-O-(1-Methylethylidene)uridine 5'-acetate; 2',3'-Isopropylideneuridine 5'-acetate; 5'-Acetyl-2',3'-O-isopropylideneuridine
EINECS	Contact for details

Quality Control

Our 2',3'-o-(Isopropylidene)Uridine 5'-Acetate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP manufacturing environments. All products undergo rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and specific tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.