Description

Guanosine 5′-Diphospho-β-L-Fucose is a crucial nucleotide-activated sugar essential for cellular glycosylation processes. This high-purity biochemical is vital for research and development in enzymology and glycobiology, where precise substrate quality is paramount. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in the study of fucosyltransferases and the biosynthesis of complex carbohydrates and glycoconjugates.

Application

• Enzymatic Substrate for Fucosyltransferases: Serves as the activated donor substrate (GDP-fucose) for in vitro enzymatic synthesis of fucosylated glycans, oligosaccharides, and glycoproteins.
• Glycobiology Research: A key reagent for studying the mechanisms of fucosylation, which is critical in cell signaling, immune response, and pathogen recognition.
• Biochemical Assay Development: Used in the development and validation of high-throughput screening assays for fucosyltransferase activity and inhibitor discovery.
• Synthesis of Glycoconjugates: Employed in chemoenzymatic pathways to create structurally defined fucosylated compounds for therapeutic and diagnostic applications.
• Cell Culture & Metabolic Labeling: Can be used in metabolic engineering and labeling studies to track fucose incorporation into cellular glycans.
• Reference Standard: Acts as a high-purity analytical standard for HPLC, LC-MS, or NMR in quality control and method development for related products.

Basic Information

Product Name	Guanosine 5′-Diphospho-β-L-Fucose
CAS No.	15839-70-0
Molecular Formula	C16H25N5O16P2
Molecular Weight	589.34 g/mol
Synonyms	GDP-Fucose; Guanosine diphosphate fucose; GDP-β-L-fucose; Guanosine 5'-(trihydrogen diphosphate), mono(6-deoxy-β-L-galactopyranosyl) ester; β-L-GDP-fucose; 6-Deoxy-β-L-galactopyranosyl guanosine diphosphate; GDP-L-fucose
EINECS	Contact for details

Quality Control

Our Guanosine 5′-Diphospho-β-L-Fucose is manufactured under stringent conditions to ensure batch-to-batch consistency and high biochemical purity suitable for research applications. Each lot is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to guarantee compliance with your technical requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	Suitable as enzyme substrate

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.