Description

2',3',5-Tri-o-Acetyl-8-Bromoguanosine is a key protected nucleoside derivative, specifically an 8-brominated guanosine with acetyl groups protecting the ribose hydroxyls. This chemical modification is crucial for enhancing stability and directing reactivity in complex synthetic pathways, particularly in nucleoside chemistry. It serves as a vital synthetic intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, enabling the development of novel antiviral agents, anticancer prodrugs, and modified oligonucleotides.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the preparation of modified RNA/DNA sequences for research and therapeutic applications.
• Biochemical Research: Serves as a substrate or precursor in enzymatic studies and metabolic pathway investigations.
• Prodrug Development: The acetyl protecting groups make it a valuable precursor in designing lipophilic prodrugs for improved bioavailability.
• Chemical Biology Probes: Utilized in the creation of labeled or tagged nucleosides for tracking and imaging studies.
• Process Chemistry: Employed in scale-up synthesis for active pharmaceutical ingredients (APIs) requiring brominated guanosine derivatives.

Basic Information

Product Name	2',3',5-Tri-o-Acetyl-8-Bromoguanosine
CAS No.	15717-45-0
Molecular Formula	C16H18BrN5O8
Molecular Weight	488.25 g/mol
Synonyms	8-Bromo-2',3',5'-tri-O-acetylguanosine; 8-Bromoguanosine 2',3',5'-triacetate; Guanosine, 8-bromo-2',3',5'-triacetate; 8-Br-Guo(Ac)3; 8-Bromo-2',3',5'-tri-O-acetyl-guanosine; 8-Bromoguanosine triacetate; 2',3',5'-Tri-O-acetyl-8-bromoguanosine
EINECS	Contact for details

Quality Control

Our 2',3',5-Tri-o-Acetyl-8-Bromoguanosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and pharmaceutical synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.