Description

1-Phenylethyl Chloroformate is a versatile and highly reactive chloroformate ester, widely used as a key chiral derivatizing and protecting agent in organic synthesis. Its primary value lies in its ability to introduce the 1-phenylethyl moiety, a common chiral auxiliary, enabling the resolution of racemic mixtures and the synthesis of enantiomerically pure compounds. This reagent is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Chiral Derivatizing Agent: For the resolution of racemic amines, alcohols, and carboxylic acids via diastereomeric derivative formation.
• Amino Acid Protection: Used in peptide synthesis to introduce the 1-phenylethyloxycarbonyl (1-Peoc) protecting group for amino functionalities.
• Pharmaceutical Intermediate: A critical building block in the asymmetric synthesis of chiral drugs and bioactive molecules.
• Agrochemical Synthesis: Employed in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Liquid Chromatography: Serves as a pre-column derivatization reagent for the chiral separation and analysis of compounds by HPLC.
• Catalyst and Ligand Preparation: Used in the synthesis of chiral catalysts and ligands for asymmetric catalysis.
• Polymer Chemistry: Can be utilized to introduce chiral centers into specialty polymers.
• Research & Development: A valuable tool in academic and industrial R&D for exploring new synthetic methodologies.

Basic Information

Product Name	1-Phenylethyl Chloroformate
CAS No.	15600-32-5
Molecular Formula	C9H9ClO2
Molecular Weight	184.62 g/mol
Synonyms	(1-Phenylethyl) chloroformate; α-Methylbenzyl chloroformate; (RS)-1-Phenylethyl chloroformate; (±)-1-Phenylethyl chloroformate; 1-Phenylethyl carbonochloridate; 1-Phenylethyl chlorocarbonate; (rac)-1-Phenylethyl chloroformate; NSC 403811
EINECS	Contact for details

Quality Control

Our 1-Phenylethyl Chloroformate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric ratio (if applicable), and impurity profiles is provided with every shipment. We support cGMP and ISO compliant manufacturing for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and highly volatile; keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Acidity (Titration)	≤ 1.0%
Specific Rotation (if chiral)	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.