Description

4-Methoxybenzyloxycarbonyl Chloride is a versatile and highly reactive acyl chloride derivative used as a key protecting group reagent in organic synthesis. Its primary value lies in its ability to introduce the 4-methoxybenzyloxycarbonyl (Moz) group, offering a protective strategy that is orthogonal to other common protecting groups like Boc and Fmoc. This compound is essential for researchers and process chemists in the pharmaceutical and fine chemical industries, particularly in the multi-step synthesis of complex molecules such as peptides, nucleotides, and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: As a protecting group reagent for amino acids, specifically for the protection of amine functionalities during solid-phase and solution-phase peptide synthesis.
• Nucleoside & Nucleotide Chemistry: Employed in the protection of exocyclic amino groups on nucleobases (e.g., adenine, cytosine, guanine) during oligonucleotide synthesis.
• Pharmaceutical Intermediate Manufacturing: A critical building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Combinatorial Chemistry: Used in the preparation of diverse chemical libraries for high-throughput screening in drug discovery programs.
• Glycochemistry: Applied in the synthesis of glycosyl donors and acceptors where selective protection of amino sugars is required.
• Fine Chemical Synthesis: Serves as a reagent for introducing the Moz group in the synthesis of specialty chemicals, catalysts, and ligands.

Basic Information

Product Name	4-Methoxybenzyloxycarbonyl Chloride
CAS No.	15586-16-0
Molecular Formula	C9H9ClO3
Molecular Weight	200.62 g/mol
Synonyms	Moz-Cl; 4-Methoxybenzyl Chloroformate; p-Methoxybenzyl Chloroformate; (4-Methoxyphenyl)methyl Carbonochloridate; 4-Methoxybenzyloxycarbonyl Chloride; PMZ-Cl; 4-Methoxybenzyloxycarbonylchloride; Carbonochloridic Acid, (4-Methoxyphenyl)methyl Ester
EINECS	Contact for details

Quality Control

Our 4-Methoxybenzyloxycarbonyl Chloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and our quality management system supports the needs of research, development, and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and highly volatile; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture absorption. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.