Description

5α-Cholest-8(14)-En-3-One is a high-purity steroidal ketone of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical synthetic intermediate and reference standard for developing novel therapeutic agents and studying sterol metabolism. It is primarily utilized by research institutions and pharmaceutical companies engaged in steroid chemistry, metabolic pathway analysis, and the development of lipid-based bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid derivatives and potential drug candidates.
• Biochemical Research: Used as a reference standard or substrate in studies of cholesterol biosynthesis, enzyme inhibition, and metabolic disorders.
• Organic Synthesis: Serves as a versatile precursor for introducing the cholestane skeleton into more complex molecular architectures.
• Analytical Standard: Employed in HPLC, GC-MS, and NMR for method development, calibration, and qualitative/quantitative analysis in sterol research.
• Material Science Research: Investigated for potential use in creating specialized organic materials and liquid crystals due to its rigid steroidal framework.

Basic Information

Product Name	5α-Cholest-8(14)-En-3-One
CAS No.	15477-87-9
Molecular Formula	C₂₇H₄₄O
Molecular Weight	384.64 g/mol
Synonyms	5α-Cholest-8(14)-en-3-one; (5α)-Cholest-8(14)-en-3-one; 3-Cholestenone, 5α-cholest-8(14)-en-3-one; 8(14)-Cholesten-3-one, 5α-; NSC 163045; 5α-Cholest-8(14)-en-3β-ol-3-one (common misnomer); δ8(14)-Cholesten-3-one
EINECS	Contact for details

Quality Control

Our 5α-Cholest-8(14)-En-3-One is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) documenting identity, purity, and all relevant specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Specification available upon request
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.