Description

2'-Deoxy-5-Iodo-5'-o-(Triphenylmethyl)Uridine is a key protected nucleoside derivative, specifically a 5-iodo-2'-deoxyuridine analog with a trityl group on the 5'-hydroxyl. This compound is critical for its role as a versatile synthetic intermediate in the development of oligonucleotides and nucleoside-based pharmaceuticals. It is primarily needed by research institutions and pharmaceutical companies engaged in antiviral drug discovery, oligonucleotide synthesis, and biochemical research, where precise molecular modifications are required.

Application

• Oligonucleotide Synthesis: Serves as a crucial building block (phosphoramidite precursor) for introducing modified nucleosides into DNA/RNA sequences.
• Antiviral Research: Used as an intermediate in the synthesis of nucleoside analogs targeting viral polymerases, particularly for herpesviruses and other DNA viruses.
• Radiopharmaceuticals: Acts as a precursor for the synthesis of iodinated nucleosides used in diagnostic imaging and targeted radiotherapy.
• Biochemical Probes: Utilized in the development of labeled nucleotides for studying DNA replication, repair mechanisms, and enzyme kinetics.
• Medicinal Chemistry: A key starting material for structure-activity relationship (SAR) studies to optimize the potency and selectivity of therapeutic nucleosides.
• Academic & Industrial R&D: Employed in basic research exploring nucleic acid chemistry and the development of novel therapeutic modalities.

Basic Information

Product Name	2'-Deoxy-5-Iodo-5'-o-(Triphenylmethyl)Uridine
CAS No.	15414-61-6
Molecular Formula	C30H27IN2O5
Molecular Weight	622.45 g/mol
Synonyms	5-Iodo-2'-deoxy-5'-O-trityluridine; 5-Iodo-5'-O-(triphenylmethyl)-2'-deoxyuridine; 2'-Deoxy-5-iodouridine 5'-(triphenylmethyl) ether; 5-Iodo-2'-deoxyuridine 5'-trityl ether; 5'-O-Trityl-5-iodo-2'-deoxyuridine; 5-Iododeoxyuridine 5'-trityl derivative; IDU-Tr; Tr-IdU
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-5-Iodo-5'-o-(Triphenylmethyl)Uridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for sensitive research and synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.