Description

3'-o-Acetyl-5-Iodo-2'-Deoxy-Uridine is a chemically modified nucleoside derivative, serving as a critical synthetic intermediate in medicinal chemistry. Its primary value lies in its role as a versatile building block for the synthesis of antiviral and anticancer nucleoside analogs, enabling precise structural modifications. This high-purity compound is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on developing novel therapeutic agents and diagnostic probes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and anticancer nucleoside drugs.
• Biochemical Research: Used as a modified substrate in enzymatic studies and for investigating DNA/RNA metabolism.
• Probe Development: Acts as a starting material for creating labeled nucleosides used in diagnostic assays and imaging.
• Antisense Oligonucleotide Synthesis: Incorporated into oligonucleotide chains to modulate binding properties and stability.
• Chemical Biology: Tool compound for studying cellular processes involving nucleotide incorporation and repair.

Basic Information

Product Name	3'-o-Acetyl-5-Iodo-2'-Deoxy-Uridine
CAS No.	15384-26-6
Molecular Formula	C11H13IN2O6
Molecular Weight	396.14 g/mol
Synonyms	5-Iodo-2'-deoxyuridine 3'-acetate; 3'-O-Acetyl-5-iodo-2'-deoxyuridine; 5-Iodo-3'-O-acetyl-2'-deoxyuridine; 1-[(2R,4S,5R)-4-Acetoxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione; 5-Iodouridine 3'-acetate; IDU 3'-acetate; 5-Iodo-dUrd 3'-acetate
EINECS	Contact for details

Quality Control

Our 3'-o-Acetyl-5-Iodo-2'-Deoxy-Uridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.