Description

2',3'-Dideoxy-5-Fluorouridine is a fluorinated nucleoside analog with significant research and pharmaceutical development potential. This compound is valued for its role as a key intermediate in the synthesis of antiviral and anticancer agents, particularly those targeting viral polymerases. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of novel therapeutic nucleosides. The product, identified by CAS number 15379-30-3, is supplied to meet the stringent purity requirements of advanced chemical synthesis and biological screening.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of advanced antiviral and antineoplastic nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving viral reverse transcriptase or DNA/RNA polymerases.
• Antiviral Drug Development: Serves as a precursor in the research and development of potential therapeutics for viral infections.
• Oncology Research: Investigated for its incorporation into prodrugs or active metabolites designed to disrupt cancer cell proliferation.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for specialized chemical entities.

Basic Information

Product Name	2',3'-Dideoxy-5-Fluorouridine
CAS No.	15379-30-3
Molecular Formula	C9H11FN2O5
Molecular Weight	246.20 g/mol
Synonyms	5-Fluoro-2',3'-dideoxyuridine; 2',3'-Dideoxy-5-fluorouridine; 5-Fluoro-ddU; 5-Fluoro-2',3'-dideoxyuridine; 1-[(2R,5S)-5-(Hydroxymethyl)oxolan-2-yl]-5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione; 5-Fluoro-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione; NSC 669699; 5-F-ddUrd
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxy-5-Fluorouridine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. Standard quality control includes identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and specific tests for related substances and residual solvents. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.