Description

(-)-Menthoxyacetyl Chloride is a chiral, optically active acid chloride derivative of menthol, widely utilized as a key chiral building block in organic synthesis. Its primary value lies in its ability to introduce the bulky, lipophilic (-)-menthyl moiety, which is instrumental in creating chiral auxiliaries, resolving agents, and stereoselective catalysts. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fragrance industries, where precise stereochemistry is critical for product efficacy and performance.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Chiral Auxiliary/Resolving Agent: Used in the separation of enantiomers (optical resolution) and in asymmetric synthesis to control stereoselectivity.
• Agrochemical Synthesis: Employed in the production of chiral pesticides and herbicides where the biological activity is enantiomer-specific.
• Flavor and Fragrance Ingredient: Serves as a precursor for synthesizing high-value chiral aroma chemicals and flavor compounds.
• Ligand and Catalyst Development: Used to prepare chiral ligands for transition metal catalysts used in asymmetric hydrogenation and other key reactions.
• Polymer Chemistry: Can be incorporated to create chiral polymers with specialized optical or material properties.
• Academic and R&D Laboratories: A valuable reagent for methodological development in synthetic organic chemistry.

Basic Information

Item	Detail
Product Name	(-)-Menthoxyacetyl Chloride
CAS No.	15356-62-4
Molecular Formula	C₁₃H₂₃ClO₂
Molecular Weight	246.77 g/mol
Synonyms	(-)-Menthyloxyacetyl chloride; L-Menthoxyacetyl chloride; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyloxyacetyl chloride; (1R,2S,5R)-Menthyloxyacetyl chloride; Menthyloxyacetyl chloride; 2-[(1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]oxyacetyl chloride; (-)-Menthyl glycolic acid chloride
EINECS	Contact for details

Quality Control

Our (-)-Menthoxyacetyl Chloride is manufactured under strict quality control protocols to ensure high chemical and optical purity. Each batch is analyzed using advanced techniques including HPLC, GC, and chiral analysis to confirm identity, assay, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties as a strong acid/organic solvent, hygroscopic (moisture-sensitive), and highly volatile nature, it must be stored in a cool (2-8°C recommended), dry, and well-ventilated area under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.