Description

7,8-Dihydro-7-Methylguanosine is a modified nucleoside derivative of guanosine, featuring a saturated bond in the imidazole ring and a methyl group at the N7 position. This specific molecular structure makes it a valuable intermediate and reference standard in advanced biochemical research and pharmaceutical development. It is primarily sought after by researchers and manufacturers in the life sciences sector for its role in studying nucleic acid chemistry, enzyme mechanisms, and as a building block for novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of nucleoside-based antiviral or anticancer drugs.
• Biochemical Research: Used as a reference standard or substrate in enzymatic studies, particularly those involving purine metabolism and nucleoside-modifying enzymes.
• Metabolite Analysis: Serves as an analytical standard in LC-MS or HPLC for the identification and quantification of modified nucleosides in biological samples.
• Academic Research: Employed in studies investigating DNA/RNA damage, repair mechanisms, and the biological activity of modified nucleosides.
• Diagnostic Reagent Development: Potential use in developing assay kits for detecting specific enzymatic activities or metabolic disorders.

Basic Information

Item	Detail
Product Name	7,8-Dihydro-7-Methylguanosine
CAS No.	15313-37-8
Molecular Formula	C11H15N5O5
Molecular Weight	297.27 g/mol
Synonyms	7-Methyl-7,8-dihydroguanosine; 7-Methyl-7,8-dihydro-9H-guanin-9-one 1-β-D-ribofuranoside; 7-Methyl-7,8-dihydro-9H-purin-9-one 1-β-D-ribofuranoside; 7-Methyl-7,8-dihydroguanine riboside; 7-Methyl-7,8-dihydroguanosine; Dihydro-7-methylguanosine
EINECS	Contact for details

Quality Control

Our 7,8-Dihydro-7-Methylguanosine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.