Description

5-Ethyl-2'-Deoxyuridine is a modified nucleoside analog of deoxyuridine, featuring an ethyl substitution at the 5-position of the uracil base. This structural modification makes it a valuable intermediate and reference standard in the research and development of antiviral and anticancer therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in nucleoside chemistry and medicinal chemistry. The compound is essential for studying enzyme interactions, metabolic pathways, and for the synthesis of more complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antiviral and antineoplastic (anticancer) nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly with thymidine kinase and other nucleoside-metabolizing enzymes.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Medicinal Chemistry: A crucial precursor for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Antiviral Agent Development: Investigated for its potential activity against DNA viruses, including herpesviruses and poxviruses.
• Labeled Compound Synthesis: Used as a starting material for the preparation of isotopically labeled (e.g., 13C, 15N, 2H) nucleosides for tracer studies.

Basic Information

Product Name	5-Ethyl-2'-Deoxyuridine
CAS No.	15176-29-1
Molecular Formula	C11H16N2O5
Molecular Weight	256.25 g/mol
Synonyms	5-Ethyl-2'-deoxyuridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-ethylpyrimidine-2,4-dione; 5-Ethyl-1-(2-deoxy-β-D-erythro-pentofuranosyl)uracil; EdU (context-specific); 5-Ethyldeoxyuridine; 2'-Deoxy-5-ethyluridine; 5-Ethyl-2'-deoxyuridine (EdU)
EINECS	Contact for details

Quality Control

Our 5-Ethyl-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material suitable for research and development applications, with the option to discuss custom purity grades (e.g., >98%, >99%) to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.