Description

4-Morpholinecarbonyl Chloride is a highly reactive acyl chloride derivative of morpholine, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the morpholinecarbonyl moiety, a key structural feature in many active pharmaceutical ingredients and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new molecules with targeted biological activity.

Application

• Pharmaceutical Intermediates: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing morpholine or amide functionalities.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the morpholine ring enhances systemic activity and bioavailability.
• Polymer Chemistry: Acts as a monomer or modifying agent for creating specialty polymers with specific thermal or solubility properties.
• Peptide Mimetics & Drug Discovery: Employed in medicinal chemistry to create peptide backbone analogs and novel heterocyclic compounds for biological screening.
• Ligand & Catalyst Development: Useful for synthesizing complex ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Serves as a precursor for surface functionalization and the creation of advanced organic materials.

Basic Information

Product Name	4-Morpholinecarbonyl Chloride
CAS No.	15159-40-7
Molecular Formula	C5H8ClNO2
Molecular Weight	149.57 g/mol
Synonyms	Morpholine-4-carbonyl chloride; 4-Morpholinecarboxylic acid chloride; Morpholinecarbonyl chloride; N-Carboxymorpholine chloride; Morpholinoformyl chloride; N-(Chloroformyl)morpholine; 4-(Chloroformyl)morpholine
EINECS	239-207-7

Quality Control

Our 4-Morpholinecarbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including assay (by titration or HPLC), identity confirmation (IR, NMR), and impurity profiling to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0 %
Purity (HPLC)	≥ 97.0 %
Water Content (KF)	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.