Description

5-Benzoxazolecarbonyl Chloride (8Ci) is a high-purity, reactive organic intermediate essential for advanced chemical synthesis. This compound is valued for its role as a versatile acylating and coupling agent, enabling the efficient construction of complex molecular architectures. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of benzoxazole-based drug candidates, including potential kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that incorporate the benzoxazole moiety.
• Material Science: Serves as a monomer or cross-linking agent for creating specialized polymers, coatings, and liquid crystals with enhanced thermal or optical properties.
• Peptide & Protein Research: Employed as an acylating reagent for modifying amino acids or for introducing benzoxazole fluorescent tags in biochemical probes.
• Organic Synthesis: A crucial reagent for constructing heterocyclic compounds and for introducing the carbonyl chloride functional group in multi-step synthetic routes.

Basic Information

Product Name	5-Benzoxazolecarbonyl Chloride (8Ci)
CAS No.	15026-76-3
Molecular Formula	C8H4ClNO2
Molecular Weight	181.58 g/mol
Synonyms	5-Benzoxazolecarboxylic Acid Chloride; 1,3-Benzoxazole-5-carbonyl Chloride; 5-Carboxybenzoxazole Chloride; Benzoxazole-5-carbonyl Chloride; 5-(Chlorocarbonyl)benzoxazole; 15026-76-3; 8Ci (Code for specific isomer/derivative)
EINECS	Contact for details

Quality Control

Our 5-Benzoxazolecarbonyl Chloride (8Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets exacting research and commercial-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.