Description

8-Bromo-2'-Deoxyadenosine is a halogenated nucleoside analog of significant importance in biochemical and pharmaceutical research. This compound serves as a versatile building block for the synthesis of modified oligonucleotides and probes, enabling advanced studies in molecular biology and drug discovery. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in nucleotide chemistry, antisense technology, and the development of novel therapeutic agents.

Application

• Oligonucleotide Synthesis: A key monomer for incorporating bromine-modified bases into DNA strands for structural studies and probe development.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving polymerases, nucleotidyltransferases, and DNA repair enzymes.
• Antisense and Antiviral Drug Development: Serves as a precursor in the synthesis of nucleotide analogs with potential therapeutic activity.
• Diagnostic Probe Fabrication: Employed in creating labeled nucleotides for fluorescence in situ hybridization (FISH) and other detection assays.
• Cross-linking Studies: The bromine atom can facilitate photo-crosslinking or serve as a handle for further chemical modifications in bioconjugation.
• Material Science: Exploration of modified nucleotides for creating functional nucleic acid nanomaterials.

Basic Information

Product Name	8-Bromo-2'-Deoxyadenosine
CAS No.	14985-44-5
Molecular Formula	C10H12BrN5O3
Molecular Weight	330.14 g/mol
Synonyms	8-Bromo-2'-deoxyadenosine; 8-Br-dA; 2'-Deoxy-8-bromoadenosine; 8-Bromodeoxyadenosine; Adenosine, 8-bromo-2'-deoxy-; 8-Bromo-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purin-6-amine; 8-Br-2'-dA; 8-Bromoadenine deoxyriboside
EINECS	Contact for details

Quality Control

Our 8-Bromo-2'-Deoxyadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.