Description

3-o-Benzyl Estradiol CAS NO 14982-15-1 is a chemically modified derivative of the natural hormone estradiol, where a benzyl group is introduced at the 3-hydroxy position. This modification enhances its stability and alters its pharmacokinetic profile, making it a valuable intermediate for advanced pharmaceutical synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for developing novel therapeutic agents and conducting metabolic studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of more complex steroidal drugs and hormone analogs.
• Research & Development: Used in biochemical research to study estrogen receptor binding, metabolism, and the structure-activity relationships of steroid hormones.
• Prodrug Development: Serves as a precursor in the design of prodrugs aimed at improving the bioavailability and targeted delivery of estradiol.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3-o-Benzyl Estradiol
CAS No.	14982-15-1
Molecular Formula	C25H30O2
Molecular Weight	362.51 g/mol
Synonyms	Estradiol 3-Benzyl Ether; 3-Benzyloxyestra-1,3,5(10)-triene-17β-ol; 17β-Estradiol 3-benzyl ether; 3-O-Benzyl-17β-estradiol; Benzyl Estradiol Ether; NSC 71964; Benzestrol precursor (related compound)
EINECS	Contact for details

Quality Control

Our 3-o-Benzyl Estradiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting standards for research and synthesis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Specification available upon request
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.