Description

Methyl 7Alpha,12Alpha-Dihydroxy-3-Oxo-5Beta-Cholan-24-Oate is a high-purity, synthetic bile acid derivative that serves as a critical intermediate in advanced pharmaceutical research and development. This compound is valued for its defined stereochemistry and functional groups, which make it an essential building block for synthesizing novel therapeutic agents and reference standards. It is primarily utilized by research institutions and pharmaceutical companies focused on metabolic, hepatic, and gastrointestinal drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel bile acid analogs and steroidal drugs targeting nuclear receptors like FXR and TGR5.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control of related compounds.
• Biochemical Research: Employed in studies investigating bile acid metabolism, transport mechanisms, and their role in liver and intestinal physiology.
• Metabolic Pathway Studies: A tool compound for exploring enzymatic pathways involved in steroid and bile acid biosynthesis and degradation.
• Drug Discovery: Integral to medicinal chemistry programs aiming to develop new treatments for cholestatic liver diseases, gallstones, and metabolic disorders.

Basic Information

Product Name	Methyl 7Alpha,12Alpha-Dihydroxy-3-Oxo-5Beta-Cholan-24-Oate
CAS No.	14772-99-7
Molecular Formula	C₂₅H₄₀O₅
Molecular Weight	420.59 g/mol
Synonyms	Methyl 7α,12α-dihydroxy-3-oxo-5β-cholan-24-oate; 3-Oxochenodeoxycholic Acid Methyl Ester; Methyl 3-Oxochenodeoxycholate; 7α,12α-Dihydroxy-3-oxo-5β-cholan-24-oic Acid Methyl Ester; 3-Ketochenodeoxycholic Acid Methyl Ester; Chenodeoxycholonic Acid Methyl Ester; 5β-Cholan-24-oic Acid, 7α,12α-dihydroxy-3-oxo-, Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 7Alpha,12Alpha-Dihydroxy-3-Oxo-5Beta-Cholan-24-Oate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; ensure the container is kept sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.