Description

3α,7α-Dihydroxy-5α-Cholan-24-Oic Acid Methyl Ester is a key methylated derivative of a primary bile acid, serving as a critical intermediate in the synthesis of more complex steroidal compounds and pharmaceutical agents. Its value lies in providing a protected carboxylic acid group, which is essential for controlled chemical modifications in advanced organic synthesis. This high-purity intermediate is primarily needed by research institutions and pharmaceutical manufacturers developing novel therapeutics, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of therapeutic bile acids, steroid hormones, and their analogs.
• Biochemical Research: Used as a standard or precursor in metabolic pathway studies, particularly those involving cholesterol and bile acid metabolism.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical and clinical laboratories.
• Organic Synthesis: Employed in medicinal chemistry for the structure-activity relationship (SAR) study and development of new drug candidates targeting nuclear receptors like FXR.
• Diagnostic Agent Development: A potential precursor for labeled compounds used in diagnostic imaging and assays.

Basic Information

Product Name	3α,7α-Dihydroxy-5α-Cholan-24-Oic Acid Methyl Ester
CAS No.	14772-98-6
Molecular Formula	C25H42O4
Molecular Weight	406.60 g/mol
Synonyms	Methyl 3α,7α-Dihydroxy-5α-cholan-24-oate; Methyl Chenodeoxycholate (5α-isomer); 5α-Chenodeoxycholic Acid Methyl Ester; 3α,7α-Dihydroxy-5α-cholanic Acid Methyl Ester; NSC 163044; 5α-CDCA Methyl Ester; Allochenodeoxycholic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our 3α,7α-Dihydroxy-5α-Cholan-24-Oic Acid Methyl Ester is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is moisture-sensitive; ensure the container is kept sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.