Description

21-Dehydrocortisol is a key steroid intermediate and metabolite of cortisol, playing a significant role in steroidogenesis research and pharmaceutical development. Its importance lies in its utility as a critical reference standard and precursor for synthesizing various corticosteroid derivatives. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors, particularly those focused on endocrine system studies, anti-inflammatory drug development, and high-purity analytical applications.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the quantification and qualification of cortisol and related steroids in analytical methods like HPLC and LC-MS.
• Biochemical Research: Serves as a crucial intermediate in studying the cortisol metabolic pathway, enzyme kinetics (e.g., 11β-hydroxysteroid dehydrogenase), and steroid hormone biosynthesis.
• Active Pharmaceutical Ingredient (API) Synthesis: Acts as a key building block in the multi-step synthesis of more complex corticosteroid drugs and their analogs.
• Diagnostic Reagent Manufacturing: Employed in the production of reagents and kits for clinical diagnostics, particularly in assays measuring adrenal function and cortisol levels.
• Metabolite Studies: Utilized in in-vitro and in-vivo studies to investigate cortisol metabolism, pharmacokinetics, and the biological activity of steroid metabolites.

Basic Information

Product Name	21-Dehydrocortisol
CAS No.	14760-49-7
Molecular Formula	C₂₁H₂₈O₅
Molecular Weight	360.44 g/mol
Synonyms	11β,17α,21-Trihydroxypregn-4-ene-3,20-dione; 21-Dehydrohydrocortisone; Reichstein's Substance L; 21-Dehydrocortisol; 11β,17α,21-Trihydroxy-4-pregnene-3,20-dione; Cortisol 21-aldehyde
EINECS	Contact for details

Quality Control

Our 21-Dehydrocortisol is produced and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), related substances, and residual solvents are provided with every shipment. We can supply material compliant with various pharmacopeial standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.