Description

1-Trimethylsilyl-3,3-dimethyl-1-butyne is a specialized organosilicon reagent featuring a protected terminal alkyne group. This compound is valued for its role as a versatile building block in advanced organic synthesis, particularly in the construction of complex molecular architectures. It is primarily used by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications requiring precise carbon-silicon bond formation.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for introducing acetylene or silyl-protected acetylene functionalities.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where the trimethylsilyl-protected alkyne acts as a crucial coupling partner.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers and silicon-containing advanced materials.
• Organic Synthesis Reagent: Employed in Sonogashira coupling, click chemistry, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand and Catalyst Development: Utilized for the preparation of novel ligands and organometallic complexes in catalysis research.
• Protecting Group Strategy: The trimethylsilyl group acts as a protective moiety for terminal alkynes, allowing for selective reactions at other sites in multi-step syntheses.

Basic Information

Product Name	1-Trimethylsilyl-3,3-dimethyl-1-butyne
CAS No.	14630-42-3
Molecular Formula	C9H18Si
Molecular Weight	154.33 g/mol
Synonyms	3,3-Dimethyl-1-(trimethylsilyl)-1-butyne; (3,3-Dimethylbut-1-yn-1-yl)trimethylsilane; Trimethyl(3,3-dimethyl-1-butyn-1-yl)silane; TMS-3,3-dimethyl-1-butyne; TMS-Dimethylbutyne; 1-Trimethylsilyl-3,3-dimethylbut-1-yne
EINECS	Contact for details

Quality Control

Our production of 1-Trimethylsilyl-3,3-dimethyl-1-butyne adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed and stored upright. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.