Description

(-)-Menthyl Chloroformate CAS NO 14602-86-9 is a chiral chloroformate ester derivative of (-)-menthol, serving as a versatile and stereoselective reagent in organic synthesis. Its primary value lies in its ability to introduce the bulky, chiral menthyl group, which is crucial for the resolution of racemic mixtures and the asymmetric synthesis of complex molecules. This high-purity intermediate is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries, where precise stereochemistry is paramount for product efficacy and regulatory approval.

Application

• Chiral Auxiliary and Resolving Agent: Widely used for the separation of enantiomers via diastereomeric derivative formation.
• Asymmetric Synthesis: Employed in the preparation of chiral carbonates, carbamates, and esters for building blocks in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Key reagent in the synthesis of stereochemically defined drugs, particularly in neurology and cardiology.
• Agrochemical Production: Used to create chiral pesticides and herbicides with enhanced biological activity and environmental profile.
• Fine Chemical Synthesis: Facilitates the production of specialty chemicals, flavors, and fragrances requiring specific optical purity.
• Polymer Chemistry: Acts as a monomer or modifying agent for creating polymers with specific chiral centers.
• Protecting Group Chemistry: The menthyl group can serve as a protecting group for alcohols and amines in multi-step syntheses.

Basic Information

Product Name	(-)-Menthyl Chloroformate
CAS No.	14602-86-9
Molecular Formula	C11H19ClO2
Molecular Weight	218.72 g/mol
Synonyms	L-Menthyl Chloroformate; (-)-Menthyl Chloroformate; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl Chloroformate; L-Menthyl Chlorocarbonate; (-)-Menthyl Chlorocarbonate; Menthyl Chloroformate; (1R,2S,5R)-Menthyl Chloroformate
EINECS	Contact for details

Quality Control

Our (-)-Menthyl Chloroformate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing identity, purity (typically >98%), enantiomeric excess, and impurity profile is provided with every shipment to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and highly volatile. Keep away from heat, sparks, open flames, and strong acids or bases. Use under an inert atmosphere for extended storage to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (Karl Fischer)	≤ 0.5%
Specific Rotation [α]20/D	-70° to -75° (c=1 in CHCl3)
Density	~1.04 g/cm³ at 20°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.