Description

5-Carboxy-2'-Deoxyuridine is a modified nucleoside derivative of deoxyuridine, featuring a carboxylic acid functional group at the 5-position of the uracil base. This structural modification makes it a valuable intermediate and building block in organic synthesis and pharmaceutical research, particularly for the development of novel antiviral and anticancer agents. It is essential for researchers and manufacturers in the fields of medicinal chemistry, biochemistry, and life sciences who require high-purity, specialized nucleosides for drug discovery and diagnostic applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based therapeutics, including potential antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate thymidylate synthase and other nucleotide metabolism pathways.
• Probe Development: Serves as a starting material for creating labeled probes or molecular tools for diagnostic and genomic research.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to design and optimize new chemical entities with enhanced biological activity.
• Academic & Industrial R&D: A critical reagent for universities, contract research organizations (CROs), and biotech companies engaged in nucleotide analog development.

Basic Information

Product Name	5-Carboxy-2'-Deoxyuridine
CAS No.	14599-46-3
Molecular Formula	C10H12N2O7
Molecular Weight	272.21 g/mol
Synonyms	5-Carboxydeoxyuridine; 5-Carboxy-2'-deoxyuridine; 5-Carboxy-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-Deoxy-5-carboxyuridine; dU-CA; 5-Carboxy-dU; 5-Carboxy-1-(2-deoxy-β-D-ribofuranosyl)uracil
EINECS	Contact for details

Quality Control

Our 5-Carboxy-2'-Deoxyuridine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.