Description

5'-Amino-2',5'-Dideoxyadenosine is a chemically modified nucleoside analog, distinguished by the amino substitution at the 5' position and the absence of hydroxyl groups at the 2' and 5' positions of the sugar moiety. This unique structure makes it a valuable intermediate for the synthesis of more complex nucleotide derivatives and probes used in biochemical research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of nucleic acid chemistry, antiviral drug discovery, and molecular biology, where precise chemical modifications are critical for studying biological mechanisms and developing novel therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside-based antiviral and anticancer prodrug candidates.
• Biochemical Research: Used as a precursor for preparing fluorescently labeled or biotinylated nucleotide probes for studying enzyme kinetics and nucleic acid interactions.
• Antisense Oligonucleotide Development: Serves as a modified monomer for incorporating into oligonucleotide sequences to alter their stability, binding affinity, or cellular uptake.
• Enzyme Substrate Analog: Acts as an inhibitor or substrate analog for enzymes like adenosine deaminase or various kinases in mechanistic studies.
• Chemical Biology Tool: Employed in the development of activity-based probes to profile and discover new therapeutic targets.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Detail
Product Name	5'-Amino-2',5'-Dideoxyadenosine
CAS No.	14585-60-5
Molecular Formula	C11H16N6O2
Molecular Weight	264.29 g/mol
Synonyms	2',5'-Dideoxy-5'-aminoadenosine; 5'-Amino-2',5'-dideoxyadenosine; 9-[(2R,5S)-5-Amino-2,5-dideoxy-β-D-ribofuranosyl]adenine; 5'-NH2-2',5'-ddA; Adenosine, 5'-amino-2',5'-dideoxy-; 5'-Amino-2',5'-dideoxyadenosine (5'-NH2-2',5'-ddAdo)
EINECS	Contact for details

Quality Control

Every batch of 5'-Amino-2',5'-Dideoxyadenosine is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, confirming compliance with your specifications and supporting research reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.