Description

8-(n-Fluoren-2-Ylacetamido)-2'-Deoxyguanosine 5'-Monophosphate is a chemically modified nucleotide derivative, specifically a guanosine monophosphate bearing a fluorenylacetamido protecting group. This compound is of significant value as a key intermediate and building block in advanced oligonucleotide synthesis, particularly for the production of labeled probes and primers. It is essential for researchers and manufacturers in the fields of molecular biology diagnostics, genetic research, and pharmaceutical development, where precise and high-purity nucleotide components are required.

Application

• Oligonucleotide Synthesis: Critical building block for the solid-phase synthesis of modified DNA and RNA strands.
• Probe and Primer Manufacturing: Used in the production of fluorescently labeled or otherwise tagged nucleic acid probes for hybridization assays (e.g., FISH) and PCR primers.
• Antisense and siRNA Research: Serves as a modified nucleotide component in the development of therapeutic oligonucleotides, including antisense agents and small interfering RNA (siRNA).
• Diagnostic Kit Development: A key raw material for in-vitro diagnostic (IVD) kits that rely on specific nucleic acid detection.
• Bioconjugation and Labeling Studies: The fluorenylacetamido group can be utilized for further chemical modifications or as a protective group in complex synthetic pathways.
• Academic and Pharmaceutical R&D: Employed in research exploring nucleic acid chemistry, structure-activity relationships, and novel drug discovery platforms.

Basic Information

Product Name	8-(n-Fluoren-2-Ylacetamido)-2'-Deoxyguanosine 5'-Monophosphate
CAS No.	14490-86-9
Molecular Formula	C25H24N6O8P
Molecular Weight	567.47 g/mol
Synonyms	8-(N-(2-Fluorenyl)acetamido)-2'-deoxyguanosine 5'-monophosphate; 8-(2-Fluorenylacetamido)-2'-deoxyguanosine 5'-monophosphate; FAM-dGMP; 8-(Fluoren-2-ylacetamido)-2'-deoxyguanosine 5'-phosphate; N-(2-Fluorenyl)-N-(2-deoxyguanosin-8-yl)acetamide 5'-monophosphate; 8-(N-Fluoren-2-ylacetamido)-2'-deoxyguanosine 5'-phosphate; Modified 2'-Deoxyguanosine-5'-monophosphate
EINECS	Contact for details

Quality Control

Our nucleotide derivatives are produced under strict quality management systems. Each batch of 8-(n-Fluoren-2-Ylacetamido)-2'-Deoxyguanosine 5'-Monophosphate undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for sensitive life science applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at low temperature. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.