Description

5'-o-Trityl-2'-Deoxyuridine is a key nucleoside derivative used as a vital building block in organic synthesis. This compound matters for its role as a protected intermediate in the production of oligonucleotides and modified nucleic acids, enabling precise control over molecular structure. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on developing novel therapeutics, diagnostic probes, and advanced genetic research tools.

Application

• Oligonucleotide Synthesis: A critical protected intermediate in the solid-phase and solution-phase synthesis of DNA and RNA sequences.
• Antiviral & Anticancer Prodrug Development: Serves as a precursor in the synthesis of nucleoside analogs with potential therapeutic activity.
• Bioconjugation & Labeling: Used to introduce modified uridine bases into biomolecules for tracking and diagnostic applications.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Academic & Industrial R&D: Employed in fundamental biochemical research and the development of novel molecular biology tools.

Basic Information

Product Name	5'-o-Trityl-2'-Deoxyuridine
CAS No.	14270-73-6
Molecular Formula	C28H26N2O5
Molecular Weight	470.52 g/mol
Synonyms	5'-O-(Triphenylmethyl)-2'-deoxyuridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-[(triphenylmethyl)oxy]pyrimidine-2,4(1H,3H)-dione; 2'-Deoxy-5'-O-trityluridine; Trityl-deoxyuridine; 5'-O-Trityl-dU; dU-Tr; 5'-O-TRT-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 5'-o-Trityl-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.