Description

Isonicotinic Acid Chloride is a versatile and highly reactive chemical intermediate essential for the synthesis of complex organic molecules. Its primary value lies in its role as a key building block for introducing the isonicotinoyl functional group, enabling the creation of compounds with targeted biological and chemical properties. This reagent is particularly critical for manufacturers in the pharmaceutical and agrochemical sectors, where it is used to develop active ingredients, including potential drug candidates and novel crop protection agents.

Application

• Pharmaceutical Synthesis: A crucial building block for the production of active pharmaceutical ingredients (APIs), particularly in the development of anti-tuberculosis agents, kinase inhibitors, and other heterocyclic compounds.
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the isonicotinoyl moiety contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in coordination chemistry and homogeneous catalysis.
• Polymer Chemistry: Employed in the modification of polymers and the synthesis of functional monomers to impart specific chemical properties to materials.
• Research & Development (R&D): A valuable tool in academic and industrial R&D labs for medicinal chemistry, chemical biology, and material science explorations.
• Fine Chemical Production: Integral to the multi-step synthesis of complex fine chemicals and specialty intermediates for various high-value industries.

Basic Information

Product Name	Isonicotinic Acid Chloride
CAS No.	14254-57-0
Molecular Formula	C6H4ClNO
Molecular Weight	141.56 g/mol
Synonyms	Isonicotinoyl Chloride; 4-Pyridinecarbonyl Chloride; 4-Pyridylcarbonyl Chloride; p-Pyridinecarbonyl Chloride; Pyridine-4-carbonyl Chloride; 4-Carbamoylpyridine Hydrochloride (related); Isonicotinic Chloride; EINECS 238-157-6
EINECS	238-157-6

Quality Control

Our Isonicotinic Acid Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements of our global customer base. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic and highly volatile nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.