Description

Guanosine 5'-Monophosphate, Monoanhydride With (Phosphonomethyl)Phosphonic Acid is a specialized nucleotide derivative with a unique bisphosphonate linkage. This compound matters for its role as a potent and stable analog of guanosine nucleotides, enabling research into enzymatic mechanisms and cellular signaling pathways without being readily hydrolyzed. It is primarily needed by biochemical researchers and pharmaceutical developers working on nucleotide metabolism, enzyme inhibitors, and the development of novel therapeutic agents targeting purinergic signaling.

Application

• Biochemical Research: Used as a stable, hydrolysis-resistant analog of GTP/GDP in enzymatic studies of GTPases, kinases, and other nucleotide-binding proteins.
• Enzyme Inhibition: Serves as a potential inhibitor for enzymes that utilize guanosine nucleotides as substrates or cofactors, aiding in mechanistic studies.
• Pharmaceutical Development: Investigated as a lead compound or intermediate for developing novel therapeutics targeting purinergic receptors or nucleotide metabolic pathways.
• Diagnostic Reagent Synthesis: Can be utilized in the synthesis of specialized reagents for diagnostic assays that detect or quantify specific enzymatic activities.
• Metabolic Pathway Analysis: Employed in tracer studies to investigate guanosine nucleotide turnover and metabolic flux in cellular systems.
• Structural Biology: Used in crystallography or NMR studies to determine the structure of protein-nucleotide complexes.

Basic Information

Item	Detail
Product Name	Guanosine 5'-Monophosphate, Monoanhydride With (Phosphonomethyl)Phosphonic Acid
CAS No.	13912-93-1
Molecular Formula	C11H17N5O12P2
Molecular Weight	473.23 g/mol
Synonyms	P1-(5'-Guanosyl)-P2-(phosphonomethyl)diphosphonate; Guanosine 5'-(β,γ-methylene)triphosphate analog; GMP-CP; GMP-PCP; Guanylyl (β,γ-methylene)diphosphonate; Guanosine 5'-[β,γ-methyleno]triphosphate; GMP-(phosphonomethyl)phosphonic acid; [[(5'-O-Guanosylphosphono)methyl]phosphonic acid]
EINECS	Contact for details

Quality Control

Our Guanosine 5'-Monophosphate, Monoanhydride With (Phosphonomethyl)Phosphonic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 90.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, alkaline solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.