Description

1-Methylpseudouridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. Its primary value lies in its role as a critical raw material for the synthesis of modified mRNA, where it enhances stability and reduces immunogenicity. This makes it an essential component for developers in the biotechnology, vaccine, and therapeutic oligonucleotide sectors seeking to optimize next-generation nucleic acid-based products.

Application

• Modified mRNA Synthesis: A key building block for producing therapeutic and prophylactic mRNA vaccines and treatments.
• Oligonucleotide Manufacturing: Used in the research and production of modified antisense oligonucleotides and siRNAs.
• Biochemical Research: Serves as a vital reagent in studies exploring RNA structure, function, and stability.
• Pharmaceutical Intermediates: Acts as a high-purity intermediate in the synthesis of novel nucleoside-based active pharmaceutical ingredients (APIs).
• Diagnostic Probe Development: Employed in creating stable, high-affinity nucleic acid probes for diagnostic assays.

Basic Information

Product Name	1-Methylpseudouridine
CAS No.	13860-38-3
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	1-Methyl-5-ribosyluracil; N1-Methylpseudouridine; m1ψ; 1-Methyl-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione; 1-Methyl-5-(β-D-ribofuranosyl)uracil; Pseudouridine, 1-methyl-; 1-Methyl-ψ; 5-Ribosyl-1-methyluracil
EINECS	Contact for details

Quality Control

Our 1-Methylpseudouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.