Description

Phosphoadenosine Diphosphoribose is a specialized nucleotide derivative that plays a crucial role in cellular signaling and metabolism. This high-purity biochemical is essential for researchers and manufacturers requiring precise tools for studying and modulating ADP-ribosylation pathways. It is primarily utilized in life science research, pharmaceutical development, and the production of diagnostic reagents.

Application

• Biochemical Research: A critical substrate and reference standard for studying poly(ADP-ribose) polymerase (PARP) enzymes and ADP-ribosylation mechanisms.
• Pharmaceutical Development: Used in the screening and characterization of novel PARP inhibitors for oncology and other therapeutic areas.
• Enzymology Studies: Serves as a cofactor or substrate in assays for sirtuins and other NAD+-dependent enzymes.
• Diagnostic Reagent Manufacturing: A key component in the formulation of high-sensitivity assay kits for cellular stress and DNA damage response.
• Cell Signaling Pathway Analysis: Employed to investigate the role of ADP-ribosylation in inflammation, gene expression, and DNA repair.
• Reference Standard: Used as a certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	Phosphoadenosine Diphosphoribose
CAS No.	13552-81-3
Molecular Formula	C15H23N5O14P2
Molecular Weight	559.32 g/mol
Synonyms	P1-(5'-Adenosyl)-P2-(5''-ribosyl)diphosphate; Adenosine diphosphoribose; ADPR; ADP-Ribose; Adenosine 5'-diphosphoribose; Adenosine 5'-diphospho-5-D-ribose; Phosphoadenosine diphosphoribose; 5'-ADP-ribose
EINECS	Contact for details

Quality Control

Our Phosphoadenosine Diphosphoribose is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.