Description

[(2R,3R,4R,5R)-5-[6-(Benzylamino)Purin-9-Yl]-3,4-Dihydroxy-Oxolan-2-Yl ]Methoxyphosphonic Acid is a high-purity nucleoside phosphonate derivative, a critical building block in advanced pharmaceutical research and development. Its primary value lies in its role as a modified nucleotide analog, enabling the study and modulation of key biological pathways. This compound is essential for researchers and manufacturers in the fields of antiviral drug discovery, oncology research, and the synthesis of novel therapeutic oligonucleotides.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleotide-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving polymerases and kinases.
• Proteomics & Genomics: Serves as a modified building block for the synthesis of labeled probes and primers.
• Antiviral Drug Development: Investigated for its potential activity against DNA and RNA viruses due to its phosphonate moiety.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Academic Research: Utilized in universities and institutes for fundamental studies on nucleotide metabolism and signaling.

Basic Information

Product Name	[(2R,3R,4R,5R)-5-[6-(Benzylamino)Purin-9-Yl]-3,4-Dihydroxy-Oxolan-2-Yl ]Methoxyphosphonic Acid
CAS No.	13484-66-7
Molecular Formula	C17H20N5O7P
Molecular Weight	437.35 g/mol
Synonyms	9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(methoxyphosphonyl)oxolan-2-yl]-6-(benzylamino)purine; 6-(Benzylamino)-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(methoxyphosphonyl)tetrahydrofuran-2-yl]purine; N6-Benzyl-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(methoxyphosphonyl)tetrahydrofuran-2-yl]adenine; N6-Benzyl-2'-deoxy-2'-methoxyphosphonyladenosine; Benzylamino Purine Nucleoside Phosphonate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP-grade manufacturing for clinical trial material supply.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.