Description

8-Bromo-2'-Deoxyguanosine is a halogenated nucleoside analog, a crucial building block in organic synthesis and biochemical research. This modified nucleoside is valued for its role as a key intermediate in the development of oligonucleotides, probes, and potential therapeutic agents. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications in drug discovery, molecular biology, and nucleic acid chemistry.

Application

• Oligonucleotide Synthesis: Serves as a critical monomer for introducing specific modifications into synthetic DNA strands for research and therapeutic applications.
• Antiviral & Anticancer Research: Used as a precursor in the development of nucleoside analogs investigated for their potential biological activity.
• Biochemical Probes: Incorporated into DNA probes and primers to study nucleic acid interactions, enzyme mechanisms, and genetic analysis.
• Medicinal Chemistry: Acts as a versatile intermediate for structure-activity relationship (SAR) studies and the synthesis of novel drug candidates.
• Academic & Industrial R&D: Employed in fundamental research exploring DNA damage, repair mechanisms, and nucleotide metabolism.

Basic Information

Product Name	8-Bromo-2'-Deoxyguanosine
CAS No.	13389-03-2
Molecular Formula	C10H12BrN5O4
Molecular Weight	346.14 g/mol
Synonyms	8-Bromo-2'-deoxyguanosine; 8-Bromo-deoxyguanosine; 2'-Deoxy-8-bromoguanosine; 8-Br-dG; 8-Bromo-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one; Guanosine, 2'-deoxy-8-bromo-; 8-Bromo-2'-deoxy-guanosine
EINECS	Contact for details

Quality Control

Our 8-Bromo-2'-Deoxyguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.