Description

Misonidazole-Guanosine Product is a chemically modified nucleoside analog, specifically a conjugate of the radiosensitizer misonidazole and the nucleoside guanosine. This compound is of significant interest in the field of radiobiology and oncology research due to its potential to enhance the cytotoxic effects of radiation on hypoxic tumor cells. It is primarily utilized by research institutions, pharmaceutical R&D departments, and academic laboratories focused on developing novel therapeutic strategies for cancer treatment. The product is supplied under stringent quality control to ensure consistency and reliability for sensitive experimental applications.

Application

• Radiobiology Research: Investigation of radiosensitization mechanisms and efficacy in hypoxic cell models.
• Oncology Drug Discovery: Serving as a key intermediate or reference standard in the development of next-generation chemoradiotherapy agents.
• Biochemical Studies: Used to study the interaction and incorporation of modified nucleosides into nucleic acids.
• Preclinical Evaluation: Assessment of pharmacokinetics, biodistribution, and therapeutic index in animal models of cancer.
• Academic Research: Fundamental studies on DNA damage and repair pathways under hypoxic conditions.

Basic Information

Product Name	Misonidazole-Guanosine Product
CAS No.	13351-91-2
Molecular Formula	C15H19N7O7
Molecular Weight	409.36 g/mol
Synonyms	1-(2-Nitro-1-imidazolyl)-3-(β-D-ribofuranosyl)guanine; Misonidazole Guanosine Adduct; NSC 261036; Guanosine, 1-(2-nitro-1H-imidazol-1-yl)-, β-D-ribofuranoside; 1-(2-Nitroimidazol-1-yl)-2',3',5'-tri-O-acetylguanosine (precursor); Ro 07-1051 Guanosine Conjugate
EINECS	Contact for details

Quality Control

Our Misonidazole-Guanosine Product is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality management system is designed to meet the exacting standards required for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.