Description

Thymidylyl-(3'-5')-2'-Deoxy-5-Fluorouridine is a dinucleotide analog, a chemically synthesized intermediate of significant importance in pharmaceutical research and development. This compound is crucial for the study and development of novel antiviral and anticancer therapeutics, particularly those targeting DNA synthesis and repair mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside-based drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex oligonucleotide analogs and prodrugs for therapeutic applications.
• Antiviral Research: Used in the development and study of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Oncology Research: Serves as a precursor in the creation of chemotherapeutic agents that interfere with cancer cell DNA replication.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to DNA polymerases and nucleotidyl transferases.
• Process Development: Used in scaling up and optimizing synthetic routes for the commercial production of active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	Thymidylyl-(3'-5')-2'-Deoxy-5-Fluorouridine
CAS No.	13276-67-0
Molecular Formula	C19H23FN4O12P
Molecular Weight	558.38 g/mol
Synonyms	5-Fluoro-2'-deoxyuridylyl-(3'→5')-thymidine; FdUMP-T; 5-Fluoro-2'-deoxyuridine 5'-(trihydrogen diphosphate), P'→5'-ester with thymidine; T-FdU; Thymidylyl-(3'→5')-5-fluoro-2'-deoxyuridine; dT-FdU; 2'-Deoxy-5-fluorouridylyl-(3'-5')-thymidine; FdUrd-(5')pp-(5')dThd
EINECS	Contact for details

Quality Control

Our Thymidylyl-(3'-5')-2'-Deoxy-5-Fluorouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.