Description

3β,17α-Bis(Trimethylsiloxy)Androst-5-Ene CAS NO 13111-27-8 is a key steroidal intermediate, specifically a silyl-protected derivative of androst-5-ene-3β,17β-diol. This compound is valued for its role in synthetic organic chemistry, where it serves as a crucial building block for the production of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and synthesis of hormone therapies and other specialized steroid compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of steroidal drugs, including hormone replacements and anti-inflammatory agents.
• Research & Development: Used in academic and industrial laboratories for exploring new synthetic pathways and creating novel steroid analogs.
• API Synthesis: Serves as a protected intermediate in the manufacture of complex Active Pharmaceutical Ingredients (APIs) requiring specific stereochemistry.
• Fine Chemical Production: Employed in the production of high-value, low-volume specialty chemicals for advanced material science and biotechnology applications.

Basic Information

Product Name	3β,17α-Bis(Trimethylsiloxy)Androst-5-Ene
CAS No.	13111-27-8
Molecular Formula	C25H46O2Si2
Molecular Weight	434.81 g/mol
Synonyms	Androst-5-ene-3β,17β-diol, 3,17-bis(trimethylsilyl) ether; 3β,17β-Bis(trimethylsiloxy)androst-5-ene; 5-Androstene-3β,17β-diol bis(trimethylsilyl) ether; 3,17-Bis-O-(trimethylsilyl)-5-androstene-3β,17β-diol; Androst-5-ene-3β,17β-diol bis(trimethylsilyl) ether; 3β,17β-Bis(trimethylsilyloxy)-5-androstene
EINECS	Contact for details

Quality Control

Our 3β,17α-Bis(Trimethylsiloxy)Androst-5-Ene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.