Description

(20S)-3β,20-Bis(Trimethylsiloxy)Pregn-5-Ene CAS NO 13110-77-5 is a high-purity, silylated steroid derivative, specifically a pregnane derivative, designed for advanced chemical synthesis and research. This compound serves as a crucial protected intermediate in the multi-step synthesis of complex steroid-based pharmaceuticals and fine chemicals, offering enhanced stability and reactivity control. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents and high-value specialty molecules.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs).
• Steroid Research & Development: Used as a standard or building block in academic and industrial research for exploring new steroid derivatives and their biological activities.
• Fine Chemical Synthesis: Employed in the production of high-value, specialized steroid compounds for various research and diagnostic applications.
• Process Chemistry: Serves as a critical intermediate in scaling up synthetic routes for steroid molecules, where the trimethylsilyl (TMS) protecting groups are essential for regioselective reactions.
• Reference Standard: Can be used as an analytical reference standard in quality control laboratories for method development and compound identification.

Basic Information

Product Name	(20S)-3β,20-Bis(Trimethylsiloxy)Pregn-5-Ene
CAS No.	13110-77-5
Molecular Formula	C29H54O2Si2
Molecular Weight	491.0 g/mol (approx.)
Synonyms	Pregn-5-ene-3β,20-diol, 3,20-bis(trimethylsilyl) ether; (20S)-3β,20-Bis-O-(trimethylsilyl)pregn-5-ene; 3β,20α-Bis(trimethylsiloxy)-5-pregnene; 5-Pregnene-3β,20α-diol 3,20-bis(trimethylsilyl) ether; 13110-77-5; BRN 2320991; Pregn-5-ene-3,20-diol, bis(trimethylsilyl) ether, (3β,20S)-
EINECS	Contact for details

Quality Control

Our (20S)-3β,20-Bis(Trimethylsiloxy)Pregn-5-Ene is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP compliance for use in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.