Description

26-Hydroxycholesterol is an endogenous oxysterol and a significant intermediate in the biosynthesis of bile acids from cholesterol. This compound matters as a key biomarker and research tool for studying cholesterol metabolism, liver function, and various disease pathways. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for drug discovery, metabolic studies, and as a reference standard.

Application

• Biomedical Research: Critical as a reference standard and intermediate in studies of cholesterol metabolism, atherosclerosis, and liver disease.
• Pharmaceutical Development: Used as a key intermediate in the synthesis of more complex steroidal compounds and potential therapeutic agents.
• Diagnostic Reagents: Serves as a calibrant or component in assay kits for quantifying oxysterols in biological samples.
• Biochemical Studies: Employed to investigate the role of oxysterols as ligands for nuclear receptors like LXR (Liver X Receptor).
• Cell Biology: Utilized in cell culture studies to examine the effects of specific oxysterols on cell proliferation, apoptosis, and inflammatory responses.

Basic Information

Product Name	26-Hydroxycholesterol
CAS No.	13095-61-9
Molecular Formula	C27H46O2
Molecular Weight	402.66 g/mol
Synonyms	(25R)-26-Hydroxycholesterol; 5-Cholestene-3β,26-diol; 3β-Hydroxy-5-cholesten-26-ol; 26-Hydroxy-5-cholesten-3β-ol; 26-HC; Cholest-5-ene-3β,26-diol
EINECS	Contact for details

Quality Control

Our 26-Hydroxycholesterol is produced and handled under a rigorous quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Keep the container in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.