Description

1-(2-Deoxy-β-D-Ribopyranosyl)Thymine is a nucleoside derivative, specifically a thymidine analog where the sugar moiety is a 2-deoxyribopyranose. This compound is a critical building block and reference standard in nucleic acid chemistry and pharmaceutical research. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of nucleoside-based therapeutics, antiviral agents, and molecular biology tools. Its defined structure is essential for studies involving DNA synthesis, modification, and the investigation of enzyme mechanisms.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of novel nucleoside analog drugs, including potential antiviral and anticancer agents.
• Biochemical Research: Used as a reference standard and substrate in enzymatic studies, particularly for research involving DNA polymerases, nucleoside kinases, and other nucleic acid-metabolizing enzymes.
• Organic Synthesis: Acts as a specialized building block for the chemical synthesis of modified oligonucleotides and other complex nucleoside derivatives for structure-activity relationship (SAR) studies.
• Analytical Standard: Employed in analytical laboratories for method development and validation in HPLC, LC-MS, or NMR for the quantification and identification of nucleosides in complex matrices.

Basic Information

Product Name	1-(2-Deoxy-β-D-Ribopyranosyl)Thymine
CAS No.	13091-56-0
Molecular Formula	C10H14N2O5
Molecular Weight	242.23 g/mol
Synonyms	Thymidine, 2'-Deoxy-; 1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluracil; 2'-Deoxythymidine; dT; 5-Methyl-2'-deoxyuridine; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione; Thymine deoxyriboside; NSC 21548
EINECS	Contact for details

Quality Control

Our 1-(2-Deoxy-β-D-Ribopyranosyl)Thymine is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.