Description

N4-Benzoylcytidine is a protected nucleoside derivative where the cytidine base is modified with a benzoyl group at the N4 position. This chemical modification is crucial for its primary role as a key synthetic intermediate and protecting group reagent in oligonucleotide synthesis, particularly in the phosphoramidite method. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity building blocks for the development of nucleic acid-based therapeutics, diagnostics, and research tools.

Application

• Oligonucleotide Synthesis: Serves as a critical protected monomer (phosphoramidite) for the solid-phase synthesis of DNA and RNA strands.
• Antiviral & Anticancer Drug Development: Used as a building block in the research and production of nucleoside analog prodrugs.
• Biochemical Research: Employed in studies of nucleic acid structure, function, and enzyme interactions.
• Diagnostic Probe Manufacture: A precursor for labeled nucleotides used in PCR, sequencing, and microarray technologies.
• Prodrug Synthesis: Facilitates the creation of masked nucleoside derivatives designed for improved bioavailability and targeted delivery.
• Academic & Industrial R&D: A valuable reagent for synthetic organic chemistry focused on nucleoside chemistry and medicinal chemistry.

Basic Information

Product Name	N4-Benzoylcytidine
CAS No.	13089-48-0
Molecular Formula	C16H17N3O6
Molecular Weight	347.32 g/mol
Synonyms	N4-Benzoylcytidine; 1-β-D-Ribofuranosyl-4-benzoylamino-2(1H)-pyrimidinone; Cytidine, N4-benzoyl-; 4-N-Benzoylcytidine; N-Benzoylcytidine; Bz-C; N4-Bz-Cytidine; 4-Benzamidocytidine
EINECS	Contact for details

Quality Control

Our N4-Benzoylcytidine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines and can provide material tailored to meet specific research or cGMP starting material requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.