Description

3,5'-Di-o-Acetyl-2'-Deoxyuridine is a key acetylated derivative of the nucleoside 2'-deoxyuridine. This compound serves as a crucial protected intermediate in the synthesis of more complex nucleoside analogs and pharmaceutical active ingredients. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in antiviral and anticancer drug development.

Application

• Pharmaceutical Intermediate: A vital building block in the synthetic pathways for novel antiviral and anticancer nucleoside drugs.
• Biochemical Research: Used as a protected precursor in studies involving DNA synthesis, repair mechanisms, and enzyme kinetics.
• Antiviral Prodrug Development: Serves as a key intermediate in the synthesis of prodrugs targeting viruses such as herpes simplex and cytomegalovirus.
• Labeled Compound Synthesis: Acts as a starting material for the preparation of isotopically labeled (e.g., 13C, 15N) nucleosides for metabolic tracing and imaging studies.
• Oligonucleotide Synthesis: Employed in the preparation of modified nucleoside phosphoramidites for solid-phase oligonucleotide synthesis.

Basic Information

Product Name	3,5'-Di-o-Acetyl-2'-Deoxyuridine
CAS No.	13030-62-1
Molecular Formula	C13H16N2O7
Molecular Weight	312.28 g/mol
Synonyms	2'-Deoxy-3',5'-di-O-acetyluridine; 2'-Deoxyuridine 3',5'-diacetate; 1-[(2R,4S,5R)-4-Acetoxy-5-(acetoxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione; 3',5'-Di-O-acetyl-2'-deoxyuridine; 2'-Deoxy-3',5'-di-O-acetyluridine; 3',5'-Diacetyl-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 3,5'-Di-o-Acetyl-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.