Description

Althiomycin is a potent antibiotic compound belonging to the thiopeptide class, characterized by its complex macrocyclic structure. This compound is valued for its significant biological activity, particularly against Gram-positive bacteria, making it a crucial entity in antimicrobial research and development. It serves as a vital reference standard and active pharmaceutical ingredient (API) for pharmaceutical companies, research institutions, and biotechnology firms engaged in developing novel therapeutic agents and studying bacterial resistance mechanisms.

Application

• Pharmaceutical Research & Development: As a key reference standard for analytical method development, quality control, and potency testing of antibiotic formulations.
• Antimicrobial Mechanism Studies: Used in biochemical and microbiological research to investigate the mode of action of thiopeptide antibiotics on bacterial ribosomes.
• Preclinical Studies: Serves as an active pharmaceutical ingredient (API) in *in vitro* and *in vivo* studies to evaluate efficacy, pharmacokinetics, and toxicity profiles.
• Veterinary Medicine Development: Potential application in the development of antimicrobial treatments for livestock and companion animals.
• Biochemical Tool Compound: Utilized in molecular biology and biochemistry labs as a selective inhibitor to probe protein synthesis pathways.
• Standards for Regulatory Compliance: Provides certified reference material for ensuring compliance with pharmacopeial standards (e.g., USP, EP) in pharmaceutical manufacturing.

Basic Information

Product Name	Althiomycin
CAS No.	12656-40-5
Molecular Formula	C42H43N13O12S6
Molecular Weight	1126.3 g/mol
Synonyms	Althiomycin; Antibiotic U-1063; U-1063; NSC-169015; Thiopeptide Antibiotic U-1063; Althiomycine; (3S,6S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S)-36-[(2S)-2-aminopropanoyl]-3,6,9,12,15,18,21,24,27,30,33-undecaazatetracyclo[33.3.1.14,8.119,23]henpentaconta-1(39),4,6,8,19,21,23,35,37,41,43,45,47-tridecaene-2,5,8,11,14,17,20,23,26,29,32,35-dodecathione
EINECS	Contact for details

Quality Control

Our Althiomycin is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identity confirmation by spectroscopic methods (IR, MS), and stringent control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	90.0% - 110.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.