Description

Amphotericin CAS NO 12633-72-6 is a potent polyene macrolide antibiotic derived from *Streptomyces nodosus*. It is a critical pharmaceutical active ingredient valued for its broad-spectrum antifungal activity, particularly against systemic fungal infections. This compound is essential for manufacturers in the pharmaceutical and biotechnology sectors producing injectable formulations and topical preparations. Its efficacy makes it a cornerstone in antifungal therapy, demanding the highest standards of purity and stability.

Application

• Pharmaceutical API: Primary active ingredient in intravenous and topical antifungal formulations.
• Antifungal Drug Production: Used in the synthesis of Amphotericin B deoxycholate (conventional formulation) and various lipid-complexed or liposomal delivery systems.
• Medical Research: Critical reference standard and tool in microbiology and pharmacology for studying fungal cell membrane ergosterol binding and antifungal mechanisms.
• Biotechnology: Employed in cell culture media as a selective agent to prevent fungal and yeast contamination.
• Veterinary Medicine: Component in antifungal treatments for systemic mycoses in animals.

Basic Information

Product Name	Amphotericin
CAS No.	12633-72-6
Molecular Formula	C47H73NO17
Molecular Weight	924.09 g/mol
Synonyms	Amphotericin B; Amphotericin B, from *Streptomyces nodosus*; Amphotericin B Complex; Ampho B; Fungilin; Fungizone; Amphocin; Anfotericina B; (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
EINECS	235-741-2

Quality Control

Our Amphotericin is manufactured and tested under strict quality management systems. Each batch is analyzed to meet stringent specifications for identity, purity, and potency, aligning with pharmacopeial standards such as USP and EP. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological quality is provided with every shipment to ensure full traceability and regulatory compliance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature of 15-25°C (59-77°F) or as specified on the label. Due to its light-sensitive and easily oxidized nature, the material must be handled in a controlled environment to maintain stability and efficacy. Keep the container dry and away from incompatible substances.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any individual impurity ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Specific Rotation	-33.0° to -40.0° (c=1 in DMF)
Bacterial Endotoxins	< 5.0 EU/mg (for injectable grade)
Microbial Enumeration	Complies with Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.