Description

β-Escin is a purified, active saponin fraction derived from the seeds of the horse chestnut tree (*Aesculus hippocastanum* L.). This compound is valued for its potent venotonic and anti-inflammatory properties, making it a critical active pharmaceutical ingredient (API) and a key component in advanced nutraceutical formulations. It is primarily sought by manufacturers in the pharmaceutical, cosmeceutical, and dietary supplement industries for developing products aimed at improving vascular health and reducing edema.

Application

• Pharmaceutical APIs: Core ingredient in prescription and OTC medications for chronic venous insufficiency (CVI), hemorrhoids, and post-operative edema.
• Dietary Supplements: Key component in capsules, tablets, and tinctures targeting circulatory support, capillary wall strengthening, and anti-swelling.
• Topical Formulations: Used in gels, creams, and ointments for the local treatment of bruises, sprains, varicose veins, and cosmetic under-eye circles.
• Cosmeceuticals: Incorporated into anti-aging and firming serums for its ability to reduce puffiness and improve skin microcirculation.
• Veterinary Medicine: Employed in treatments for equine and canine limb edema and circulatory issues.
• Research & Development: Used as a standard or active agent in pharmacological studies related to inflammation, vascular permeability, and oxidative stress.

Basic Information

Product Name	β-Escin
CAS No.	11072-93-8
Molecular Formula	C55H86O24
Molecular Weight	1131.3 g/mol
Synonyms	Aescin; Escin; β-Aescin; β-Aescin; Escine; Venostasin; Reparil; Aesculus hippocastanum saponin; Horse Chestnut Extract (standardized)
EINECS	234-301-4

Quality Control

Our β-Escin is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical and nutraceutical use. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, with specifications alignable to relevant pharmacopeial monographs (e.g., Ph. Eur., USP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and in original packaging until use to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Conforms to reference retention time
Assay (HPLC)	≥ 95.0% (β-Escin)
Loss on Drying	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Microbiological Control	Meets Ph. Eur. criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.