Description

Oligomycin C CAS NO 11052-72-5 is a potent macrolide antibiotic belonging to the oligomycin complex, primarily recognized for its specific inhibition of mitochondrial ATP synthase. This compound serves as a critical biochemical tool in life science research for studying cellular energy metabolism, oxidative phosphorylation, and mitochondrial function. It is essential for researchers and manufacturers in the fields of biochemistry, pharmacology, and molecular biology who require high-purity inhibitors for mechanistic studies and assay development.

Application

• Biochemical Research: As a specific inhibitor of the F0 subunit of mitochondrial ATP synthase (Complex V) to study oxidative phosphorylation and energy coupling.
• Pharmacology & Toxicology: Used in mechanistic studies to investigate the role of mitochondrial dysfunction in disease models and to screen for compounds that modulate ATP production.
• Cell Biology: A key reagent for inducing mitochondrial membrane potential collapse and studying apoptosis, autophagy, and other cell death pathways linked to bioenergetics.
• Antibiotic Research: Serves as a reference standard and active component in studies exploring the structure-activity relationships of macrolide antibiotics and their modes of action.
• Diagnostic Assay Development: Utilized in the development and validation of in vitro assays designed to measure mitochondrial function and ATPase activity in various biological samples.

Basic Information

Product Name	Oligomycin C
CAS No.	11052-72-5
Molecular Formula	C45H74O12
Molecular Weight	791.1 g/mol
Synonyms	Oligomycin C; Oligomycin C complex; 28,34-Didehydrooligomycin A; Antibiotic 66-40C; NSC 106977; Oligomycin A, 28,34-didehydro-; (1R,2S,3S,4R,6S,7E,9E,11S,12R,13S,14S,16R,18R,19R,20S,21S,22S,24S,26S,27R,29S,30S,32S,33S,34R)-33-[(2R,3S,4S,5S,6R)-4-(Dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-4,6,11,13,14,16,18,20,21,24,26,29,30,32,34-pentadecahydroxy-3,7,9,19,22-pentamethyl-27-(1-methylpropyl)-1,15-dioxacyclopentatriaconta-7,9-diene-2,12,17,25-tetrone
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Quality Control

Our Oligomycin C is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is analyzed via advanced chromatographic and spectroscopic methods to confirm identity and potency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment, supporting compliance with rigorous laboratory standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is easily oxidized; containers should be sealed under an inert atmosphere after opening and allowed to equilibrate to room temperature before use to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single unknown impurity ≤ 2.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.