Description

Thevetin CAS NO 11018-93-2 is a potent cardiac glycoside complex, primarily composed of Thevetin A and Thevetin B, extracted from the seeds of plants in the *Thevetia* genus. This compound is valued for its significant pharmacological activity, particularly its positive inotropic effect on the heart, making it a critical intermediate and reference standard in pharmaceutical research and development. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and natural product sectors who are developing or quality-testing cardiovascular drugs and botanical extracts.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified reference material (CRM) for the identification, assay, and impurity profiling of cardiac glycoside-based drug substances and products in pharmacopeial testing (e.g., USP, EP).
• Cardiovascular Drug Research: Used as a key active pharmaceutical ingredient (API) intermediate or a biochemical tool in preclinical research for studying heart failure mechanisms and developing new cardiotonic agents.
• Natural Product & Botanical Extraction: Employed as a marker compound for the standardization, quality control, and authentication of botanical extracts derived from *Thevetia peruviana* (Yellow Oleander) and related species.
• Biochemical & Pharmacological Studies: Utilized in in-vitro and in-vivo studies to investigate its mechanism of action on the Na+/K+-ATPase pump and its effects on myocardial contractility.
• Analytical Chemistry: Acts as a critical calibration standard in advanced analytical techniques such as High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), and Thin-Layer Chromatography (TLC) for method development and validation.

Basic Information

Product Name	Thevetin
CAS No.	11018-93-2
Molecular Formula	C42H66O19 (for Thevetin B)
Molecular Weight	874.97 g/mol (for Thevetin B)
Synonyms	Thevetin B; Thevetoside; Cerberin; Thevetia glycoside; 3'-O-Methylnerifolin; 3'-O-Methyl-4'-dehydro-neriifolin; NSC 89382; Cardiac glycoside from Thevetia peruviana
EINECS	Contact for details

Quality Control

Our Thevetin is produced and tested under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by chromatographic and spectroscopic methods. We support compliance with cGMP guidelines for API intermediates and can provide materials tailored to meet specific pharmacopeial (USP/EP) or in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0% (Thevetin B)
Loss on Drying	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.