Description

16β-Acetoxy-5-(β-D-Glucopyranosyloxy)-14-Hydroxy-19-Oxo-5β-Bufa-3,20,22-Trienolide is a complex bufadienolide glycoside, a class of compounds known for their potent biological activity. This high-purity compound is of significant interest for advanced pharmaceutical research and development, particularly in the study of cardiac glycosides and their mechanisms. It serves as a critical reference standard and a key intermediate for researchers and manufacturers in the life sciences sector.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of bufadienolide compounds in research and quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic building block in the development of novel therapeutic agents.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of cardiac glycosides and their interaction with biological targets like Na+/K+-ATPase.
• Natural Product Isolation & Standardization: Acts as a benchmark compound for the identification and standardization of bufadienolides in complex natural extracts, such as those from toad venom or traditional medicines.
• Preclinical & Pharmacological Studies: Utilized in in-vitro and in-vivo models to evaluate potential cardiotonic, anticancer, or other biological effects.

Basic Information

Product Name	16β-Acetoxy-5-(β-D-Glucopyranosyloxy)-14-Hydroxy-19-Oxo-5β-Bufa-3,20,22-Trienolide
CAS No.	11005-49-5
Molecular Formula	C32H44O12
Molecular Weight	620.69 g/mol
Synonyms	16β-Acetoxy-14-hydroxy-19-oxo-5β-bufa-3,20,22-trienolide 5-O-β-D-glucopyranoside; Bufalin 3-O-β-D-glucoside acetate derivative; Gamabufotalin 3-O-glucoside acetate; 19-Oxobufalin glucoside acetate; 5β,14β-Dihydroxy-19-oxo-3β-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy]bufa-20,22-dienolide (related intermediate); Bufadienolide C-3 glucoside acetate; 11005-49-5
EINECS	Contact for details

Quality Control

Our 16β-Acetoxy-5-(β-D-Glucopyranosyloxy)-14-Hydroxy-19-Oxo-5β-Bufa-3,20,22-Trienolide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.