Description

(3Alpha,5Beta,12Alpha)-3,12-Dihydroxy-7-Oxocholan-24-Oic Acid Methyl Ester is a high-purity bile acid derivative and a key synthetic intermediate in pharmaceutical research and development. This compound is valued for its defined stereochemistry and structural role in the synthesis of more complex therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel drug candidates, particularly in the fields of hepatology, gastroenterology, and metabolic disease.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel therapeutic bile acids and steroidal drugs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating bile acid metabolism, receptor interactions (e.g., FXR, TGR5), and related biological pathways.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and process optimization for active pharmaceutical ingredient (API) manufacturing.
• Metabolite Synthesis: Used to synthesize specific metabolites for pharmacokinetic and toxicological studies during drug development.

Basic Information

Product Name	(3Alpha,5Beta,12Alpha)-3,12-Dihydroxy-7-Oxocholan-24-Oic Acid Methyl Ester
CAS No.	10538-65-5
Molecular Formula	C₂₅H₄₀O₆
Molecular Weight	436.58 g/mol
Synonyms	7-Oxolithocholic Acid Methyl Ester; Methyl 3α,12α-Dihydroxy-7-oxo-5β-cholan-24-oate; 3α,12α-Dihydroxy-7-oxo-5β-cholan-24-oic Acid Methyl Ester; 7-Ketolithocholic Acid Methyl Ester; Methyl 7-Ketolithocholate; 7-Oxo-LCA Methyl Ester
EINECS	Contact for details

Quality Control

Our (3Alpha,5Beta,12Alpha)-3,12-Dihydroxy-7-Oxocholan-24-Oic Acid Methyl Ester is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, and custom synthesis to meet specific purity or packaging requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.