Description

Thymine, 3-Oxide (7Ci,8Ci) is a chemically modified derivative of the nucleobase thymine, characterized by the oxidation at the 3-position. This compound is of significant interest in advanced biochemical and pharmaceutical research, serving as a key intermediate and reference standard. It is primarily utilized by research institutions and chemical manufacturers engaged in the development of novel nucleoside analogs, prodrugs, and for studying oxidative DNA damage and repair mechanisms. Our supply ensures high purity and batch-to-batch consistency critical for sensitive applications.

Application

• Pharmaceutical Research & Development: As a critical building block and impurity reference standard in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Studies: For investigating the mechanisms and consequences of oxidative damage to DNA, particularly the role of thymine oxidation products.
• Academic Research: Used in universities and research institutes as a specialty reagent for studies in bioorganic chemistry, radiobiology, and free radical biology.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for analytical method development and validation in HPLC, LC-MS, and other techniques.
• Prodrug Synthesis: An intermediate in the design and synthesis of prodrugs aimed at improving the bioavailability and targeting of therapeutic nucleosides.

Basic Information

Product Name	Thymine, 3-Oxide (7Ci,8Ci)
CAS No.	10501-89-0
Molecular Formula	C5H6N2O3
Molecular Weight	142.11 g/mol
Synonyms	3-Hydroxythymine; 5-Methyl-2,4(1H,3H)-pyrimidinedione 3-oxide; Thymine 3-N-oxide; 5-Methyluracil 3-oxide; 3-Oxothymine; Thymine N-oxide; 1,5-Dihydro-5-methyl-1-oxopyrimidine-2,4-dione; 5-Methyl-3-oxo-1,2,3,4-tetrahydropyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our Thymine, 3-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets stringent research-grade specifications. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.