Description

(3Alpha,5Beta,6Alpha,12Alpha)-3,12-Bis(Acetyloxy)-6-Bromo-7-Oxocholan-24-Oic Acid Methyl Ester is a high-purity, synthetic bile acid derivative with a brominated ketone functional group. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) for the research and development of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in steroid chemistry and metabolic pathway studies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel steroid-based drugs and bioactive molecules.
• Research Chemical: Used in academic and industrial research for studying bile acid metabolism, receptor interactions, and chemical biology.
• Process Development: Serves as a reference standard and starting material for scaling up synthetic routes in process chemistry.
• Metabolite Synthesis: Employed in the preparation of potential drug metabolites for analytical and toxicological studies.
• Chemical Probe Development: Utilized to create tools for investigating biological pathways related to cholesterol and lipid homeostasis.

Basic Information

Product Name	(3Alpha,5Beta,6Alpha,12Alpha)-3,12-Bis(Acetyloxy)-6-Bromo-7-Oxocholan-24-Oic Acid Methyl Ester
CAS No.	10452-63-8
Molecular Formula	C₂₉H₄₁BrO₇
Molecular Weight	581.54 g/mol
Synonyms	6-Bromo-3α,12α-diacetoxy-7-oxo-5β-cholan-24-oic Acid Methyl Ester; Methyl 3α,12α-Diacetoxy-6α-bromo-7-oxo-5β-cholan-24-oate; 6α-Bromo-3α,12α-diacetoxy-7-oxo-5β-cholan-24-oic Acid Methyl Ester; 6-Bromo-7-oxolithocholic Acid 3,12-Diacetate Methyl Ester; 6-Bromodehydrocholic Acid Diacetate Methyl Ester; Methyl 6-Bromo-3α,12α-diacetoxy-7-oxo-5β-cholan-24-oate; (3α,5β,6α,12α)-3,12-Bis(acetyloxy)-6-bromo-7-oxocholan-24-oic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our production of (3Alpha,5Beta,6Alpha,12Alpha)-3,12-Bis(Acetyloxy)-6-Bromo-7-Oxocholan-24-Oic Acid Methyl Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Every lot is characterized using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.